氨基脲急性暴露对雄性斑马鱼(Daniorerio)的内分泌干扰效应研究_NormalPdf.pdfVIP

543Vol.54,No.3

20235OCEANOLOGIAETLIMNOLOGIASINICAMay,2023

(Daniorerio)

*

11,2

(1.061001;2.061001)

(semicarbazide,SEM),

1101001000µg/LSEM

96h,17β-(E2)(T)

HPG,SEM

,1µg/LSEMHPGs

(sGnRH)sGnRHmRNA,(FSH)FSHβ(LH)LHβ

P45019B(CYP19B)CYP19B,101001000µg/LSEM

sGnRHmRNAc(cGnRH)cGnRHCYP19B

;SEM3β-(3β-HSD)3β-HSDP45017

(CYP17)CYP17P45011A(CYP11A)CYP11AmRNA,P45019A

(CYP19A)CYP19A,T,E2,SEM

HPG,,

;;HPG;;

Q142.8doi:10.11693/hyhz20220900234

(semicarbazide,SEM),1.0~41.5μg/L,

,(,,

2021)SEM,,γ-

(,2003)(gamma-aminobutyricacid,GABA)N-

,-D-(N-methyl-D-aspartatereceptors,

(Stadleretal,2015)2003,NMDARs)(Maranghietal,2009,

,2010);,

,,(,2008;

(Maranghi,2021)Maranghi(2009)SEM

etal,2009)(2010),

,17β-(17β-estradiol,E2)

(46.41±21.22)μg/L,6.46,Gao(2014),SEM

μg/kgYang(2021)vtg

*,ZR2014DZ001;