IgD及其受体功能和信号研究进展.doc

  IgD 及其受体功能和信号研究进展# 吴育晶，黄琼，陈文生，戴杏，魏伟** （安徽医科大学临床药理研究所， 抗炎免疫药物教育部重点实验室，合肥，230032） 5 10 15 20 25 30 摘要：自从 1965 年首次发现免疫球蛋白 D (Immunoglobulin D, IgD)以来，IgD 一直是最为神 秘的抗体家族成员。从鱼类到人类进化发展中， IgD 一直保留并发挥重要的免疫学功能。 IgD 在免疫系统中兼具受体和配体的双重身份：作为膜受体，在 B 细胞早期发育中 IgD 可在 IgM 缺失时替代 IgM 的功能；在炎症和免疫平衡的监测中，IgD 起到调节免疫应答和维持免 疫系统平衡的作用；作为配体的 IgD 可以通过与其受体(IgD receptor, IgD-R)结合并激活下游 信号通路，介导 T 细胞的活化及 T 、B 细胞的相互作用。本文就 IgD 与 IgD-R 的结构特点、 生理功能、相关的信号通路，IgD 异常与疾病的关系及以 IgD 及 IgD-R 为靶点的药物治疗前 景等研究进展做一综述。 关键词：IgD；IgD 受体；结构；功能；信号通路 中图分类号：R392.5；R967 Research progress on the function and signaling pathways of Immunoglobulin D and its receptor WU Yujing, HUANG Qiong, CHEN Wensheng, DAI Xing, WEI Wei (Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine , Ministry of Education, Hefei 230032, China) Abstract: Immunoglobulin D (IgD) has remained a mysterious antibody class since firstly founded in 1965. Although the structure of IgD has been very dynamic throughout evolution, it has been preserved in evolution from fish to human for important immunological functions. IgD plays an important role in immune system not only as a receptor but also as a ligand: as a membrane receptor, IgD can substitute IgM when IgM is absent in early B cell development, it also can arrange an surveillance system between immunity and inflammation，taking part in immune response and regulating immune system balance; as a ligand, IgD may take part in immune response through cross-linking with its putative binding receptor (IgD-R) and activate the signaling pathway to activate T cell and to influence the T-B cell interaction. This article makes a brief summary not only on the structure characteristic, physiology function, related signaling pathways of IgD and IgD-R, but also on the abnormal expression of IgD in diseases and the IgD/ IgD-R targeting therapy prospect. Key words: IgD；IgD receptor；structure；function；signaling pathway 35 0 引言 免疫球蛋白 D (Immunoglobulin D, IgD)