6-羟基多巴处理后星形胶质细胞铁转运能力的改变.docVIP

6-羟基多巴处理后星形胶质细胞铁转运能力的改变.doc

  1. 1、本文档共8页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
  5. 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
  6. 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们
  7. 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
  8. 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
 6-Hydroxydopamine Promotes Iron Traffic in Primary Cultured Astrocytes# ZHANG Haoyun, SONG Ning, XU Huamin, SHI Limin, JIANG Hong, XIE Junxia** 5 10 15 20 25 30 35 40 (Department of Physiology, Medical College of Qingdao University, ShanDong QingDao 266071) Abstract: It is well known that disrupted brain iron homeostasis was involved in Parkinson’s disease (PD). Astrocytes, the major glial cell type in the central nervous system, are largely responsible for iron distribution in the brain. However, how iron metabolism changes of astrocytes in PD are not fully elucidated. In the present study, we first observed that both iron influx and efflux were enhanced with 10 μM 6-OHDA treatment for 24 hrs in primary cultured astrocytes. In accordance with this iron traffic modulations, iron importer divalent metal transporter 1 with iron responsive element (DMT1+IRE) and exporter ferroportin 1 (FPN1) were up-regulated in these cells. Iron regulatory protein 1 (IRP1) showed a dynamic regulation with 6-OHDA treatment, as indicated by a moderate up-regulation at 12 hrs, however, down-regulation at 24 hrs. These results suggest that 6-OHDA might promote iron transport rate in astocytes by regulating iron transporters and IRP1 expression. Keywords: Parkinson’s disease; astrocytes; iron; iron transport; oxidative stress 0 Introduction Parkinson’s disease (PD) is a neurodegenerative disorder characterized in its late phase by the sustained loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) [1,2,3]. Two of pathological features in PD are the aggregation of oxidative stress and nigral iron deposit [4,5,6,7]. Excessive iron enhances the production of oxygen radicals and thus is associated with oxidative damage and eventually neuronal degeneration in this region. So far most of the studies are concerned with iron accumulation in melanized dopaminergic neurons. Little is known about the contribution of astrocytes to this iron accumulation under oxidative circu

文档评论(0)

文档分享 + 关注
实名认证
文档贡献者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档