Ska2FAM33A一个参与细胞周期调控与肿瘤发生的新基因.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2013, 35(2): 234–239 http ://www.cj Ska2/FAM33A: 一个参与细胞周期调控与 肿瘤发生的新基因 , , , , 濛 1 2 1 2 1 2 1 2* 谢 宇 张 莹 张春冬 卜友泉 1 ( 重庆医科大学生物化学与分子生物学教研室, 重庆400016; 2重庆医科大学分子医学与肿瘤研究中心, 重庆400016) 摘要 Ska2(spindle and KT associated 2), 也称FAM33A(family with sequence similarity 33, member A), 是一个最近鉴定的参与细胞周期调控与肿瘤发生发展的新基因。现有研究初步证实, Ska2参与组成Ska复合体, 在有丝分裂中期纺锤体检验点关闭中起重要作用; Ska2在小细胞肺癌和 乳腺癌中呈现表达上调, 可通过糖皮质激素受体等途径参与细胞增殖调节和肿瘤发生发展; NF-κΒ 和CREB等转录因子可能参与Ska2的表达调控。Ska2有望成为一个恶性肿瘤诊断和靶向治疗的新 靶点。 关键词 Ska2; FAM33A; 细胞周期; 肿瘤; 基因表达调控 Ska2/FAM33A: A Novel Gene Implicated in Cell Cycle and Tumorigenesis Xie Mengyu1,2, Zhang Ying1,2, Zhang Chundong1,2, Bu Youquan1,2* 1 ( Department of Biochemistry and Molecular Biology, ChongQing Medical University, Chongqing 400016, China ; 2Molecular Medicine and Cancer Research Center, ChongQing Medical University, Chongqing 400016, China) Abstract Ska2 (spindle and KT associated 2), also known as FAM33A (family with sequence similarity 33, member A), is a recently identified gene involved in cell cycle regulation and tumorigenesis. It has been demonstrated that Ska2, along with its coworkers Ska1 and Ska3, constitutes the Ska complex which plays a critical role in the maintenance of the metaphase plate and/or spindle checkpoint silencing during mitosis. RNAi-mediated Ska2 depletion results into a prolonged checkpoint-dependent delay in a metaphase