以黄原胶为助悬剂的Pluronic温敏原位凝胶的处方筛选与初步评价.pdf

Pharmaceuticals201 中国医药工业杂志ChineseJournalof 1，42(8) 刘畅，侯佳朋，陆伟跃，刘瑜幸 (复旦大学药学院药剂学教研室，上海201203) 摘要：以减少药物沉降、再分散性良好和不对原位凝胶温敏性产生不利影响为主要筛选指标，考察了难溶性药物奥硝唑 的温敏原位凝胶中泊洛沙姆和助悬剂黄原胶用量等处方因素，筛选得到一种药物能稳定混悬、具有良好流变学性质和温 F127 F68 敏性适宜的泊洛沙姆．助悬剂复配方案。所得最优处方为黄原胶0．1％，Pluronic16％，Pluronicl％，奥硝唑 lO％，氯化钠O．5％，尼泊金乙酯0．2％。制品凝胶化温度35．9℃，凝胶硬度适宜，药物沉降缓慢，再分散性和热稳定性 良好。 关键词：原位凝胶；黄原胶；助悬剂；难溶性药物；奥硝唑 中图分类号：R944．9文献标志码：A 文章编号：1001—8255(2011)08．0600-04 Formulation and EvaluationofPluronic Preliminary Optimization XanthanGum insituGelwitha of SuspendingAgent LIU Jiapeng，LUWeiyue，LIUYu奉 Chang，HOU 201203) (Dept．ofPharmaceutics,SchoolofPharmacy,FudanUniversity,Shanghai ABSTRACT：Toscreenacombinationof and with stability,goodrheological poloxamersuspendingagentsuperior andsuitable influencesoftheamountofxanthanand intheformulationof property thermosensitivity,the gumpoloxamers omidazoleinsire were with and asindexes．The gel investigatedsedimentation，redispersionthermosensitivityoptimum formulationwasasfollows：0．1％xanthan gum，16％PluronicF127，1％Pluronic and witha of35．9℃had and 0．2％ethylparaben．Theproductgelationtemperature properhardness，goodredispersion thermal stability． Words：insitu soluble Key gel；xanthangum；suspendingagent；sl