决奈达隆_治疗房颤的新型抗心律失常药.pdf

Pharm Care Res 2008 Dec; 8( 6) 璟, 等. 决奈达隆: 治疗房颤的新型抗心律失常药 # 417 # # # : 刘 璟, 秦永文(, 200433) [ ] , , , , 800 mg/d , [ ] ; ; ;; [ ] R 972. 2 [ ] A [ ] 1671-2838(2008) 06-0417-04 Dronedarone: anovel antiarrhythmicdrugforthetreatmentof atrial fibrillation LIU Jing, QIN ong-wen( Department of Cardiovasology, Changhai Hospital, Second M ilitary Medical University, Shanghai 200433, China) [ABSTRACT] Dronedarone is a noniodinated benzofurane derivative, which is structurally and characteristically similar to amiodarone. It has been developed to overcome the iodine-associated adverse effects of amiodarone.The animal experiments and several clinical trials have been accomplished.T he clinical trials indicated efficacy, safety and low adverse reactions of dronedar- one ( 800 mg/d) in patients with atrial fibrillation. [KEY ORDS] dronedarone; amiodarone; atrial fibrillation; arrhythmia; review [Pharm Care Res, 2008,8( 6) : 417-420] , [2] 10%, Lalev†e , , (I Na) , 01 3 3 Lmol/ L I Na 23%97%, , , , , (I K ) L [ I Ca(L) ] , ; 3 , [3] [4] ,, , Chatelain ) ) ) ( droneda- B-, rone) ÑÒÓÔ, 1 , [5, 6] 11 1 分子结构和药动学 Sun , , ; 4 , , , , 90% , (APD90) , APD90 ,24 h, ( Vmax ) [7] 30~ 50 d, QT c