05国外知名有机化学家解析.ppt

国外著名有机化学家简介 Stuart L. Schreiber Honors And Awards Some main prize NSF presidential young investigator award, 1985; Thieme-IUPAC award in synthetic organic chemistry, 1992; Eli Lilly award in biological chemistry, ACS, 1993; Dupont Merck young investigator award of the protein society, 1995; Tetrahedron prize for creativity in organic chemistry, 1997; Derek Barton medal, 1999; Alfred Bader award in bioorganic and bioinorganic chemistry, ACS, 2000; Thieme-IUPAC Award in Synthetic Organic Chemistry The Thieme-IUPAC Prize is awarded every two years on the occasion of IUPACs International Conference on Organic Synthesis (ICOS) to a scientist under 40 years of age, whose research has had a major impact on the field of synthetic organic chemistry. The Prize is sponsored jointly by Georg Thieme Verlag, IUPAC, and the Editors of Synthesis, Synlett, Science of Synthesis, and Houben-Weyl. Schreiber’s Research Biologists study pathways and networks by perturbing them and observing the result. Whereas these perturbations most often result from mutations in genetic investigations, they can also result from small organic molecules. Numerous examples exist of small molecules being used to explore immunology, yet these examples have been brought to light generally on a case-by-case basis. Rather than using small molecules on an ad hoc basis, Stuart Schreibers laboratory is attempting to use them in a systematic way, so that virtually any area of biology can be examined with small molecules. Schreiber’s Research Beginning in the mid-1980‘s, Schreiber and his co-workers studied the molecular mechanisms of the immunosuppressive agents cyclosporin（环孢菌素）, FK506 and rapamycin（雷伯酶素）, which led to new insights into two signaling networks central to hematopoietic cell function. Using a synthetic analog of FK506, they were able to show that these immunosuppressants “bridge” two proteins. Both the complex of cyclosporin （环孢菌素） with