BALBc Mice Vaccinated with Leishmania major Ribosomal Proteins Extracts Combined with CpG Oligodeoxynucleotides Become Resistant to Disease Caused by a Secondary Parasite Challenge英文文献资料.docVIP
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BALBc Mice Vaccinated with Leishmania major Ribosomal Proteins Extracts Combined with CpG Oligodeoxynucleotides Become Resistant to Disease Caused by a Secondary Parasite Challenge英文文献资料
HindawiPublishingCorporation
JournalofBiomedicineandBiotechnology
Volume2010,ArticleID181690,9pages
doi:10.1155/2010/181690
ResearchArticle
BALB/cMiceVaccinatedwithLeishmaniamajor
RibosomalProteinsExtractsCombinedwithCpG
OligodeoxynucleotidesBecomeResistanttoDisease
CausedbyaSecondaryParasiteChallenge
LauraRam′?rez,
1
SalvadorIborra, JimenaCort′es, PedroBonay, CarlosAlonso,
2 1 1 1
andManuelSoto
1
ManoelBarral-Netto,
3
1
2
3
DepartamentodeBiolog′?aMolecular,CentrodeBiolog′?aMolecularSeveroOchoa,(CSIC-UAM),Nicol′asCabrera1,
UniversidadAut′onomadeMadrid,28049Madrid,Spain
UnidaddeInmunolog′?aViral,CentroNacionaldeMicrobiolog′?a,InstitutodeSaludCarlosIII,Crta.PozueloKm2,
28220Majadahonda,Madrid,Spain
CentrodePesquisasGonc?aloMoniz,Fundac??aoOswaldoCruz(FIOCRUZ),RuaWaldemarFalcao,121,Candeal,
40.296-710Salvador-Bahia,Brazil
CorrespondenceshouldbeaddressedtoManuelSoto,msoto@cbm.uam.es
Received22July2009;Revised11September2009;Accepted29October2009
AcademicEditor:JorgeMorales-Montor
Copyright?2010LauraRam′?rezetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,
whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.
Leishmaniasis is an increasing public health problem and e?ective vaccines are not currently available. We have previously
demonstrated that vaccination with ribosomal proteins extracts administered in combination of CpG oligodeoxynucleotides
protects susceptible BALB/c mice against primary Leishmania major infection. Here, we evaluate the long-term immunity to
secondaryinfectionconferredbythisvaccine.WeshowthatvaccinatedandinfectedBALB/cmicewereabletocontrolasecondary
Leishmaniamajorchallenge,sincenoin?ammationandverylownumberofparasiteswereobservedinthesiteofreinfection.
In addition, although an increment in the parasite burden was observed in the draining lymph nodes of the primary site of
infectionwedidnotdetectedin?ammatorylesio
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