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Association between the JC Polyomavirus Infection and Male Infertility 英文参考文献
AssociationbetweentheJCPolyomavirusInfectionand
MaleInfertility
ManolaComar1,NunziaZanotta2,EleonoraCroci1,ImmacolataMurru2,RobertoMarci3,CeciliaPancaldi4,
OrnellaDolcet2,StefaniaLuppi2,MonicaMartinelli2,ElenaGiolo2,GiuseppeRicci1,MauroTognon4*
1Institute for Maternal and Child Health - IRCCS ‘‘Burlo Garofolo’’– Trieste, University ofTrieste,Trieste, Italy, 2Institute for Maternal and Child Health - IRCCS‘‘Burlo
Garofolo’’–Trieste,Trieste,Italy,3SectionofObstetricsandGynaecology,SchoolofMedicineandSurgery,UniversityofFerrara,Ferrara,Italy,4SectionofCellBiologyand
MolecularGenetics,SchoolofMedicineandSurgery,UniversityofFerrara,Ferrara,Italy
Abstract
In recent years the incidence of male infertility has increased. Many risk factors have been taken into consideration,
including viral infections. Investigations into viral agents and male infertility have mainly been focused on human
papillomaviruses,whilenoreportshavebeenpublishedonpolyomavirusesandmaleinfertility.Theaimofthisstudywasto
verifywhetherJCvirusandBKvirusareassociatedwithmaleinfertility.Matchedsemenandurinesamplesfrom106infertile
malesand100fertilemales,ascontrols,wereanalyzed.SpecificPCRanalyseswerecarriedouttodetectandquantifylargeT
(Tag)codingsequencesofJCVandBKV.DNAsequencing,carriedoutinTagJCV-positivesamples,wasaddressedtoviral
protein1(VP1)codingsequences.TheprevalenceofJCVTagsequencesinsemenandurinesamplesfrominfertilemales
was34%(72/212),whereastheBKVprevalencewas0.94%(2/212).Specifically,JCVTagsequencesweredetectedin24.5%
(26/106)ofsemenand43.4%(46/106)ofurinesamplesfrominfertilemen.Insemenandurinesamplesfromcontrolsthe
prevalencewas11%and28%,respectively.Astatisticallysignificantdifference(p,0.05)inJCVprevalencewasdisclosedin
semenandurinesamplesofcasesvs.controls.AhigherJCviralDNAloadwasdetectedinsamplesfrominfertilemalesthan
incontrols.InsamplesfrominfertilemalestheJCvirustype2strain,subtype2b,wasmoreprevalentthanubiquitoustype
1.JCVtype2straininfectionhasbeenfoundtobeassociatedwithmaleinfertil
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