Association of Adenovirus 36 Infection with Obesity and Metabolic Markers in Humans A Meta-Analysis of Observational Studies 英文参考文献.docVIP
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Association of Adenovirus 36 Infection with Obesity and Metabolic Markers in Humans A Meta-Analysis of Observational Studies 英文参考文献
AssociationofAdenovirus36InfectionwithObesityand
MetabolicMarkersinHumans:AMeta-Analysisof
ObservationalStudies
TomohideYamada,KazuoHara*,TakashiKadowaki
DepartmentofDiabetesandMetabolicDiseases,GraduateSchoolofMedicine,UniversityofTokyo,Japan
Abstract
Background:SeveralstudieshaveshownthatAdenovirus36(Ad36)influencestheriskofobesityinhumans.Clarifyingthe
relationshipbetweenAd36infectionandobesitycouldleadtomoreeffectiveapproachesforthemanagementofobesity.
The objective of this study was to conduct a meta-analysis to confirm the influence of Ad36 infection on obesity and
metabolicmarkers.
Methodology/Principal Findings: We searched MEDLINE and the Cochrane Library for pertinent articles (including their
references) published between 1951 and April 22, 2012. Only English language reports of original observational studies
were included in this meta-analysis. Data extraction was performed independently by two reviewers. Weighted mean
differences(WMDs)andpooledoddsratios(ORs)with95%confidenceintervals(95%CIs)werecalculatedusingtherandom
effectsmodel.Of237potentiallyrelevantstudies,10cross-sectionalstudies(n=2,870)conformedtotheselectioncriteria.
PooledanalysisshowedthattheWMDforBMIofAd36infectioncomparedwithnon-infectionwas3.19(95%CI1.44–4.93;
P,0.001).Sensitivityanalysisrestrictedtostudiesofadultsyieldedasimilarresultof3.18(95%CI0.78–5.57;P=0.009).The
increased risk of obesity associated with Ad36 infection was also significant (OR: 1.9; 95% CI: 1.01–3.56; P=0.047). No
significant differences were found in relation to total cholesterol (P=0.83), triglycerides (P=0.64), HDL (P=0.69), blood
glucose(P=0.08),waistcircumstance(P=0.09),andsystolicbloodpressure(P=0.25).
Conclusion/Significance:Ad36infectionwasassociatedwiththeriskofobesityandweightgain,butwasnotassociated
with abnormal metabolic markers including waist circumstance. It suggests that Ad36 infection is more associated with
accumulationofsubcutaneousfatthanthatofvisceralfat.TherelationshipbetweenAd36andobesity
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