壳寡糖前驱体的制备与表征.pdfVIP

第 29卷第8期 东北大学学报(自然科学版) Vo1.29 ,No.8 2008 年 8 月 lournal of North臼stem University(Natural Science) Aug. 2008 壳寡糖前驱体的制备与表征 李岚红，张宇宏，社延华，张宝砚， (东北大学理学院，辽宁沈阪 11(嗣4) 擂 要:研究了一种简单的用化学选择性来保护壳寡糖氨基的方法，用于制备 N-邻苯二甲酸住壳寡 糖，这种可榕性 N-保护壳寡糖前驱体对壳寡塘进一步进行可控化学修饰非常重要.通过控制邻苯二甲酸哥 与壳寡糖的摩尔比、反应时间及反应温度制备了取代度不同、产物组成均一的环状酿亚胶型邻苯二甲散化壳 寡糖前驱体，并用红外光谱法、X 射线衍射对 N- 邻苯二甲酸化壳寡糖的取代度、分子结构等进行了表征.结 果表确:随着邻苯二甲酸哥与壳寡糖氨基摩尔比的增加，产物的取代度增大，与有机洛剂的亲和性增加.XRD 也表畴，尽管壳寡糖链上悬挂很大的取代基，但N 邻苯二甲鼓化壳寡糖却具有结品性. 关键词:壳寡糖;前驱体;氨基:化学选择性保护;结品性 中理分类号: 0636.1 文献标识码:A 文章编号: 1005-3026(2∞8)08-1143-04 Preparation and Characterization of Chitosan Oligosaccharide Precursor LI Feng-hong , ZHANG Yu-hong , DU Yan-hua , ZHANG~yαη (School of Scíences , Northeastem University, Shenyang 11∞饵， China. Correspondent: ZHANG 忌IO-y.缸， prof臼脏， E-mail: baoyanz出吨@hotmail.回到) Abstract: A simple and ∞nvenient procedure for chemoselective protection of the amino groups of chitosan oligosaccharidεwas developed to prepare N-phthaloyl-chit岱an oligosaccharide. lt is indispensable to the soluble N-protected precursor to modìfy chemoselectively the reactions of chitosan oligl部accharide. A series of N-phthaloyl-chitζ腿n olig佣accharide precursors were prepared at different levels of substítution with the 盟mεhomogeneity of ∞nstítuents by way of ∞ntrolling the mole ratio of phthalic anhydride to chitü!咄l01ig，臼accharide and reaction timel temperature. The level of substitution and molecular structure of the precursors prepared were characterized with FTIR and XRD.τhεresults showed that the levelof substitution and affinity of organic solvents both increase with the increasíng mole ratÎo as above. XRD patte口1s showed that the N-phthaloyl-chit岱an