奥曲肽联合泮托拉唑治疗上消化道大出血疗效研究.doc

奥曲肽联合泮托拉唑治疗上消化道大出血疗效研究[摘要] 目的 探讨奥曲肽联合泮托拉唑治疗上消化道大出血的疗效。方法 选择76例上消化道大出血病例，随机分两组，治疗组38例，对照组38例。治疗组采用除常规的抗休克、扩容、泮托拉唑抑酸、止血、输血、上氧、监测生命体征，记24小时出入量，综合治疗外，先皮下注射奥曲肽0.1mg，继而用5%葡萄糖250ml加奥曲肽0.3mg,小剂量持续静滴，24小时总量0.6mg，连续使用5-7天。对照组采用常规的抗休克、扩容、泮托拉唑抑酸、止血、输血、上氧、监测生命体征，记24小时出入量，综合治疗。结果 治疗组：显效率65.8%，有效率31.6%，无效为2.6%，总有效率：97.4%,有效病例于1-3天后开始进流质饮食，生命体征平稳，精神状态逐渐好转。对照组：显效率52.6%，有效率23.7%，无效为23.7%，总有效率：76.3 %。结论 在消化道大出血使用奥曲肽联合泮托拉唑治疗疗效显著，两药联合应用，可产生协同作用，从而使出血得到迅速控制，值得临床推广使用。 [关键词] 奥曲肽; 泮托拉唑; 上消化道出血 [中图分类号] R573.2[文献标识码] A[文章编号] 1005-0515（2011）-04-09-01 The Analysis on the Application of Octreotide with Pantoprazole In Hemorrhage of Upper Digestive Tract YANG Hui (The Second Affiliated Hospital of Guiyang Medical College, Kaili City, Guizhou Province 556000) [Abstract] Objective To evaluate the effect of Octreotide with Pantoprazole to hemorrhage of upper digestive tract.MethodTo select 76 cases of hemorrhage of upper digestive tract,and divide them into two groups randomly with 38 patients in experimental group and 38 patients in control group. In addition to the regular use of anti-shock,expansion,pantoprazole acid suppression,stanching,blood transfusion, the oxygen, monitoring vital signs, 24-hour intake and output record for Comprehensive treatment,the treatment group are firstly given the subcutaneous injection of octreotide 0.1mg,then added with 250ml of 5% glucose andoctreotide 0.3mg for low dose continuous infusion, 0.6mg of total 24 hours, and 5 to 7 days of continuous use. The control group are given the regular use the anti-shock, expansion, pantoprazole acid suppression,stanching,blood transfusion, the oxygen,monitoring vital signs, 24-hour intake and output record for Comprehensive treatment. ResultThe significant efficiency of the treatment group was 65.8%, efficiency 31.6%, inefficiency was 2.6%, the total effective rate is 97.4%.the effective cases start into the liquid diet after 1 to 3 days with stable vital signs,and mental state gradually improved. The signif