the relationship between telomere length and mortality in chronic obstructive pulmonary disease (copd)端粒长度和死亡率之间的关系在慢性阻塞性肺疾病(copd).pdfVIP
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the relationship between telomere length and mortality in chronic obstructive pulmonary disease (copd)端粒长度和死亡率之间的关系在慢性阻塞性肺疾病(copd)
The Relationship between Telomere Length and
Mortality in Chronic Obstructive Pulmonary Disease
(COPD)
1 1 2 1 1 1 1
Jee Lee , Andrew J. Sandford , John E. Connett , Jin Yan , Tammy Mui , Yuexin Li , Denise Daley ,
3 4 1 1
Nicholas R. Anthonisen , Angela Brooks-Wilson , S. F. Paul Man , Don D. Sin *
1The Providence Heart and Lung Institute at St. Paul’s Hospital, The UBC James Hogg Research Centre Department of Medicine, The University of British Columbia,
Vancouver, British Columbia, Canada, 2 Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America,
3 Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada, 4 Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency,
Vancouver, British Columbia, Canada
Abstract
Some have suggested that chronic obstructive pulmonary disease (COPD) is a disease of accelerated aging. Aging is
characterized by shortening of telomeres. The relationship of telomere length to important clinical outcomes such as
mortality, disease progression and cancer in COPD is unknown. Using quantitative polymerase chain reaction (qPCR), we
measured telomere length of peripheral leukocytes in 4,271 subjects with mild to moderate COPD who participated in the
Lung Health Study (LHS). The subjects were followed for approximately 7.5 years during which time their vital status, FEV1
and smoking status were ascertained. Using multiple regression methods, we determined the relationship of telomere
length to cancer and total mortality in these subjects.
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