the relationship between water intake and foetal growth and preterm delivery in a prospective cohort study水的摄入量之间的关系和胎儿生长和早产前瞻性群组研究.pdfVIP
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the relationship between water intake and foetal growth and preterm delivery in a prospective cohort study水的摄入量之间的关系和胎儿生长和早产前瞻性群组研究
Wright et al. BMC Pregnancy and Childbirth 2010, 10:48
/1471-2393/10/48
RESEARCH ARTICLE Open Access
The relationship between water intake and foetal
growth and preterm delivery in a prospective
cohort study
1* 2 3
J Michael Wright , Caroline S Hoffman , David A Savitz
Abstract
Background: Interpretation of previous associations between water intake and adverse birth outcomes is
challenging given that amount and type of water consumed can be non-specific markers of exposure or
underlying behavioural characteristics. We examined the relationship between water intake measures and adverse
birth outcomes in participants from three study sites in the United States.
Methods: Using a prospective cohort study, we examined daily intake of bottled, cold tap, total tap, and total
water in relation to birth weight and risk of small-for-gestational-age (SGA) among term births and risk of preterm
delivery.
Results: Based on water consumption data collected between 20-24 weeks of gestation, the adjusted mean birth
weight was 27 (95% confidence interval [CI]: -34, 87), 39 (95% CI: -22, 99), and 50 (95% CI: -11, 110) grams higher
for the upper three total water intake quartiles ( 51-78, 78-114, and 114 ounces/day) compared to the lowest
quartile (≤ 51 ounces/day). Adjusted birth weight results were similar for bottled water, cold tap water, and total
tap water intake. An exposure-response gradient was not detected for either preterm delivery or SGA with
increasing total water intake and total tap water intake, but adjusted relative risks for all three upper quartiles were
below 1.0 (range: 0.6-0.9) for SGA.
Conclusion: These data suggest that high water intake may be associated with higher mean birth weight
following adjustment for confounding.
Backgroun
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