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the role of monoclonal antibodies in the management of leukemia单克隆抗体在白血病的管理
Pharmaceuticals 2010, 3, 3258-3274; doi:10.3390/ph3103258
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
The Role of Monoclonal Antibodies in the Management
of Leukemia
Ali Al-Ameri 1, Mohamad Cherry 2, Aref Al-Kali 1 and Alessandra Ferrajoli 1,*
1 Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston,
TX 77005, USA
2 Department of Internal Medicine, Hematology Oncology section, Oklahoma University Health
Sciences Center, 700 N.E. 13th Street, Oklahoma City, OK 74103, USA
* Author to whom correspondence should be addressed; E-Mail: aferrajo@;
Tel.: +1-713-792-2063.
Received: 20 September 2010 / Accepted: 18 October 2010 / Published: 18 October 2010
Abstract: This article will review the monoclonal antibodies more commonly used in
leukemias. In the last three decades, scientists have made considerable progress
understanding the structure and the functions of various surface antigens, such as CD20,
CD33. The introduction of rituximab, an anti CD20 monoclonal antibody, had a great
impact in the treatment of lymphoproliferative disorders. Gemtuzumab, an anti CD 33
conjugated monoclonal antibody has activity in acute mylegenous leukemia (AML). As
this field is undergoing a rapid growth, the years will see an increasing use of monoclonal
antibodies in hematological malignancies.
Keywords: monoclonal Abs; leukemia; CLL; AML; ALL
1. Introduction
In 1900, speaking of monoclon
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