盐酸维拉帕米不溶性微孔膜缓释胶囊的制备和体外.pdf

盐酸维拉帕米不溶性微孔膜缓释胶囊的制备和体外释药试验 张福志1 2* 2 1 1 2 ，傅红兴 ，陈密特 ，周文碧 ，王和美 ，赵应征 (1.平阳县人民医院药剂科，浙江 温州325400 ；2.温州医 学院药学院，浙江 温州 325035) 摘要：目的 制备盐酸维拉帕米不溶性微孔膜胶囊剂并研究其体外释药行为。方法 以乙酸纤维素(CA)为囊膜材料，聚 乙二醇400 为增塑剂，蘸胶法制备囊壳，并从致孔剂种类、比例、不同释放条件和内容物配方等因素考察盐酸维拉帕米 的释药行为，通过扫描电镜对释药后囊壳结构进行观察。结果 选用泊洛沙姆为致孔剂，增加其用量能使药物释放加快； 囊内添加柠檬酸，能使药物释放更平稳。结论 维拉帕米不溶性微孔膜缓释胶囊在体外能得到缓释效果，通过胶囊内微 环境的控制，可以得到平稳的体外释药速度。 关键词：不溶性微孔膜；胶囊；盐酸维拉帕米；缓释 中图分类号：R943.41 文献标志码：A 文章编号：1007-7693(2011)06-0537-05 Preparation of Insoluble Porosity Membrane Sustained-release Capsules Containing Verapamil Hydrochloride and Investigation on Their in Vitro Drug Release 1 2* 2 1 1 2 ZHANG Fuzhi , FU Hongxing , CHEN Mite , ZHOU Wenbi , WANG Hemei , ZHAO Yingzheng (1.Department of Pharmacy, County People's Hospital of Pingyang, Wenzhou 325400, China; 2.School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China) ABSTRACT: OBJECTIVE To prepare insoluble porosity membrane capsules containing verapamil hydrochloride and investigate their in vitro drug release. METHODS With cellulose acetate(CA) used as capsule materials and PEG400 as plasticizer, the insoluble porosity membrane capsules were prepared by dip plastic method. Effects of different types and ratio of receiving medium and different porosity membrane capsules on drug release behavior were investigated. With scanning electron microscope, surface and cross-section of capsule shell were also observed. RESULTS Drug release rate enhanced with increasing pore-formers Poloxamer (F68). Profile of drug release showed a stable trend when citric acid was added in capsule formulation. CONCLUSION Insoluble porosity membrane capsules of verapamil