2020年2月28日大讲堂全身麻醉对中枢神经系统发育的影响1.ppt

主要内容;主要内容;全身麻醉=伤害？？？;主要内容;全身麻醉机制在受体水平大体上有两种;NMDA受体;GABA-A受体;中枢神经系统发育的特点;NMDA受体与脑发育;;GABA与脑发育;;MK801引起未成熟大脑神经元死亡;;激动GABA受体引起的神经元死亡;;;;;结论;主要内容;问题;;no evidence that a single, relatively brief anesthetic exposure in connection with hernia repair in infancy reduced academic performance at age 15 or 16 yr after adjusting for known confounding factors ;;;Repeated exposure to anesthesia and surgery before the age of 2 was a significant independent risk factor for the later development of LDs;;5225对双胞胎，304个在3岁以前有一次或多次麻醉手术史，排除本身存在发育或行为异常者，神经外科手术者，心脏手术者，腭裂者，膈肌手术者;Thus, there is no evidence for a causal relationship between anesthesia administration and later learning-related outcomes in this sample.;the Western Australian Pregnancy Cohort (Raine) Study, 1989~ 1992, originally evaluate the long-term effects of prenatal ultrasound;现有临床研究结果的不一致性;主要内容;On going projects;PANDA Pediatric Anesthesia and NeuroDevelopment Assessment ;;;2012年，项目论坛首次纳入了泌尿外科、普通外科、整形科和眼科临床专家 2014年4月，纳入放射科、神经内科、心脏内科以及重症医学等学科专家 目前进展：研究对象招募即将结束 ;GASGeneral anesthesia and apoptosis Study;;MASKMayo Anesthesia Safety in Kids Study ;;;总结;;;;;Thanks for your attention!