赵仑_09_march_erp高级希的培训班讲座(6).ppt

赵仑_09_March_ERP高级培训班讲座(6);;P2;Language Processing & Linguistics; N400; N400;Processing of incongruous mental calculation problems- An arithmetic N400 effect;;;PMN (phonological mismatch negativity) (Connolly, et al, 1990, 1992, 1994) A negative-going response preceding the N400 in auditory modality is peaked between 270 and 300 ms after the onset of the terminal word Reflecting acoustic-phonetic processing of the initial segment of the word (e.g, the sentence-final word), possibly the initial phoneme Connolly & Phillips, 1994 ----- Investigating the independence of PMN from N400 under 4 conditions;4 conditions: Phoneme mismatch - Semantic mismatch (PMM-SMM): Joan fed her baby some worm nose (milk) ----PMN & N400 Phoneme mismatch - Semantic match (PMM-SM): They left the dirty dishes in the kitchen (sink) ----PMN Phoneme match - Semantic mismatch (PM-SMM): Phi put some drops in his icicles (eyes) ----N400 Phoneme match - Semantic match (PM-SM): At night the old woman locked the door;Connolly & Phillips, 1994;Connolly & Phillips, 1994;The differences between the MMNs elicited by comes and come recorded at FCz are shown for the experiments where these words were presented out of context (red curves) and in context (blue curves) The ungrammatical deviant stimulus elicited a larger MMN than the correct sentence at left-anterior recording sites and the cortical sources of the grammatical effects revealed a main source in the left frontal cortex. ;(Pulverm?ller, et al, 2007);神经精神疾病的认知功能障碍： 认知过程 认知功能 脑机制及其评估;（1）对病例的选择和说明要详细，是否得到治疗，效果如何等，有利于结果的说明； （2）详细说明实验过程中被试的表现情况； （3）临床研究中对照组的选择要与实验组尽量匹配； （4）实验设计是生命，实验技术是根本； （6）设计的简单性、被试任务的完成性； （7）溯源分析不是必要的，基本波形分析（潜伏期、幅值、脑区分布）更重要； （8）个案研究的重要性。;海马损伤 & P3b、P3a;The patients after head injury may notice errors – the Ne is not significantly different from normal – but not be able to cope with them – the Pe wave is significant reduced. ;（Bentin S, et al, 1999）;Prosopagnosia - the inability to