扶正消癌Ⅰ号方治疗晚期结直肠癌疗效观察医学.doc

扶正消癌Ⅰ号方治疗晚期结直肠癌疗效观察医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：扶正消癌Ⅰ号方治疗晚期结直肠癌疗效观察医学 1 1 临床资料 3 2 结果 5 3 讨论 6 文2：艾迪注射液治疗晚期结直肠癌的研究临床医学 8 1 资料与方法 9 2 结果 10 3 讨论 11 参考文摘引言： 12 原创性声明（模板） 13 文章致谢（模板） 14 正文 扶正消癌Ⅰ号方治疗晚期结直肠癌疗效观察医学 文1：扶正消癌Ⅰ号方治疗晚期结直肠癌疗效观察医学 Abstract：ObjectiveTo investigate the efficacy of Fuzhengxiaoai Decoction Ⅰon advanced colorectal cancer patients without adequate performance status (PS). Methods 50 advanced colorectal cancer patients were enrolled in the study, and randomly divided into research group and control group, 25 cases in each group. In research group, patients were treated with Fuzhengxiaoai Decoction Ⅰon day1 to day 14, the regimen was performed every 2 weeks; in control group, patients were treated only with best supportive care (BSC), after at least two cycles treatment, the efficacy, toxicity and quality of life (QOL), median survival time (MST), overall survival (OS) in both groups were were 23 and 22 patients into statistics in research group and control respectively, the difference of efficacy on symptoms of traditional Chinese medicine (TCM) between research group and control were significant ( χ2=, P=), QOL was higher than in control (P), however, the incidence of toxicity between two groups was not significant (P), MST and OS were also not significant between two groups (P). ConclusionFuzhengxiaoai Decoction Ⅰis efficient on symptoms of can enhance QOL suggesting its value in advanced colorectal cancer patients without adequate PS. Key words：Fuzhengxiaoai Decoction Ⅰ; Colorectal canceadvanced; Best supportive care; Traditional Chinese medicine 随着国人饮食结构的改变及不良生活习惯,结直肠癌（colorectal cancer, CRC）发病率有增高的趋势，结直肠癌是消化道肿瘤中发病率最高的恶性肿瘤之一，由于早期症状无特异性，很多患者就诊时已属晚期，失去手术根治的机会，虽然近年来奥沙利铂(oxaliplatin，OXA)和依立替康(CPT-11)为主的方案在转移性结直肠癌治疗中奠定了基石［1～3］，但由于毒性反应等原因限制了其使用，且化疗的施行对患者体能的要求较高，许多晚期CRC患者由于体能不达标无法开展化疗，因此，对晚期CRC患者开展多学科治疗是客观需要，中医药治疗经过多年临床实践证明对肿瘤化疗具有较好的减毒增效作用,我们曾报道自拟扶正消癌Ⅰ号方治疗中晚期上消化道肿瘤取得较好效果［4］, 本研究中, 我们观察了该方对晚期转移性结直肠癌体能状况达不到化疗标