基于比例优势模型和优化试验设计的计算机临床仿真（临床医学资料）.docVIP

基于比例优势模型和优化试验设计的计算机临床仿真（临床医学资料） 文档信息 属性： F-01NHS7，doc格式，正文20529字。质优实惠，欢迎下载！ 适用： 作为医学资料、临床医学资料写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：基于比例优势模型和优化试验设计的计算机临床仿真 1 1 引 言 3 2 方法 3 3 结果和讨论 6 4 结论 10 文2：计算机数字化仿真测试设计 10 2系统框架 11 3数字化仿真环境的设计 11 4结束语 15 参考文摘引言： 16 原创性声明（模板） 17 文章致谢（模板） 17 正文 基于比例优势模型和优化试验设计的计算机临床仿真（临床医学资料） 文1：基于比例优势模型和优化试验设计的计算机临床仿真 Clinical Trial Simulation based on Proportional Odds Model and Doptimal Design ZHENG Dan1, ZHU Ling, LIU Yajie, SHI Xinling ( Engineering Department, Information School, Yunnan Univeity, Kunming 650091，China) Abstract：To introduce the clinical trial simulation based on proportional odds model. Taking naratriptan as example, which is a novel agonist for the acute treatment of migraine, we adopted the method of D-optimal design to simulate the drug clinical trail of adopted proportional odds model and analysed different facto such as time and does how to impact Pain Relief(PR). Then, the D-optimal design was used to maximize the determinant of Fisher information matrix(FIM) and compared the clinical trial simulated results. Finally more reasonable dose and time of the desig were curve of the PR probability expressed PR trend directly, reflecting administration dose and time on the impact of PR. According to the simulated results, we found that there was a delay of the effect with respect to the plasma concentration in “effect” compartment and the probability of having a specific Pain Relief (PR) score depended on different facts such as dose, the effect sampling time and model paramete. Clinical trial simulation is a useful tool for the new drug development and it can be used for the quantitative assessment of the controllable facto to the effect of treatment. Key words：Proportional odds model; D-optimal design; Fisher information matrix; Clinical trials simulation 1 引 言 计算机临床实验仿真(CTS)运用计算机模拟技术从前期研究中获得信息，揭示试验设计中变量和假设对结果的影响，预测和评价不同研究方案可能产生的结果。CTS适用于实际系统费用昂