GCSF对儿童急性淋巴细胞白血病诱导缓解治疗作用（医学资料）.docVIP

GCSF对儿童急性淋巴细胞白血病诱导缓解治疗作用（医学资料） 文档信息 主题： 关于“医学心理学”中“肿瘤学”的参考范文。 属性： F-01L808，doc格式，正文22216字。质优实惠，欢迎下载！ 适用： 作为医学资料、医学资料写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：GCSF对儿童急性淋巴细胞白血病诱导缓解治疗作用 1 1 对象与方法 2 2 结 果 4 3 讨 论 5 文2：不同大剂量甲氨蝶呤对儿童急性淋巴细胞白血病微小残留病变的影响 6 1资料与方法 7 参考文摘引言： 10 原创性声明（模板） 11 文章致谢（模板） 12 正文 GCSF对儿童急性淋巴细胞白血病诱导缓解治疗作用（医学资料） 文1：GCSF对儿童急性淋巴细胞白血病诱导缓解治疗作用 ［ABSTRACT］ObjectiveTo investigate the effect of recombinant human granulocyte colonystimulating factor (rhGCSF) on acute lymphoblastic leukemia (ALL) in children undergoing inductive therapy. MethodsFortysix children who were newly diagnosed as having ALL with granulocytopenia (ANC≤×109/L) were treated with either rhGCSF (study group) or Chinese herbal medicine, Fu Fang Zao Fan Wan (control group) during inductive chemotherapy. The relevant clinical menifestatio of ALL and the therapeutic effect were assessed. ResultsEffect of the chemotherapy between the two groups was not significantly different. The recovery time of neutropenia, peistence of fever, hospital stay and antibiotics used were significantly shorter in the study group than in the control, and the incidence of infection was also significantly lower. Side effects of rhGCSF were not CSF can hasten the recovery of ANC, shorten the time of granulocytopenia, reduce infection. Supplementary treatment with GCSF is effective and safe during the inductive chemotherapy of ALL in children. ［KEY WORDS］leukemia, lymphoblastic; infection; granulocyte colonystimulating factor; neutropenia 化学疗法是目前治疗儿童急性淋巴细胞白血病（ALL）的最主要方法。联合化疗可使儿童ALL的完全缓解率达95%以上。但骨髓抑制期白细胞的降低可致严重的医院感染，特别在诱导期更易发生，已成为死亡的主要原因之一。粒细胞集落刺激因子(GCSF)能促进粒系造血祖细胞的增殖和分化，加速成熟中性粒细胞的生成，并能加强其游走和吞噬功能［1］。本研究对46例初治ALL诱导化疗后中性粒细胞减少病儿给予GCSF治疗，对其疗效和不良反应进行了探讨,现报告如下。 1 对象与方法 对象 2003年1月～2005年1月，我院初治ALL诱导化疗后中性粒细胞减少（中性粒细胞绝对值≤×109/L）病儿46例，分为2组。治疗组24例，男16例，女8例；年龄2～11岁；其中高危6例，标危18例。对照组22例，男15例，女7例；年龄2～10岁；其中高危5例，标危17例。两组免疫分型均为前B淋巴细胞和早前B淋巴细胞型。初诊时骨髓原细胞+幼稚淋巴细胞为～。两组年龄、性