四逆汤对肾性高血压大鼠肾及心脑病变的影响（医学资料）.docVIP

四逆汤对肾性高血压大鼠肾及心脑病变的影响（医学资料） 文档信息 主题： 关于“医学心理学”中“内科学”的参考范文。 属性： F-01L80M，doc格式，正文21833字。质优实惠，欢迎下载！ 适用： 作为医学资料、医学资料写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：四逆汤对肾性高血压大鼠肾及心脑病变的影响 1 1 材料和方法 3 2 结 果 5 3 讨 论 6 文2：四逆汤对肾性高血压大鼠主要靶器官AngⅡ和CGRP表达的影响医学 7 1 材料和方法 8 2 结 果 10 3 讨 论 11 参考文摘引言： 12 原创性声明（模板） 13 文章致谢（模板） 13 正文 四逆汤对肾性高血压大鼠肾及心脑病变的影响（医学资料） 文1：四逆汤对肾性高血压大鼠肾及心脑病变的影响 ［ABSTRACT］ObjectiveTo study the effects of Sinitang on histopathologic changes in kidney, heart and brain in renal hyperteive female Wistar rats (n=24) were evenly and randomly divided into normal control (NC) group, renal hyperteion (RH) group and Sinitangtreated (ST) group. The renal hyperteive models were established by doublecliping the renal arteries. Sinitang was given through an intragastric tube to the rats in ST group for four weeks, while normal saline was given to those in RH group at the same time, and no any treatment given to the rats in NC group. The histopathologic changes of each group were then observed. ResultsExteive pathological changes were noted in the kidney, heart and brain in RH group compared with that in NC group. The pathologic structure changes of kidney in ST group were obviously lightened than that in RH group, and the wall of afferent arteriole of glomerulus of ST group was thinner than that in RH group (F=,q=,P); the average cross section area of myocardial fiber in ST group was smaller than that in RT group (F=,q=,P); while no significant difference in brain histopathologic changes was noticed. Conclusioinitang can relieve the pathologic changes in kidney and heart of renal hyperteive rats by reducing blood pressure. ［KEY WORDS］Sinitang; hyperteion, renovascular; pathologic status, kidney; heart; brain; rats 四逆汤在临床上广泛应用于休克、腹泻、麻疹重症、胃下垂、放射性白细胞减少症、肝痈、复发性口疮、咳喘等虚寒性急慢性疾病的治疗，究其药理机制，与高血压的发病机制颇有关联［1,2］。然而，目前还未见关于四逆汤治疗高血压的报道。高血压的并发症多而重，特别是对心、脑、肾等重要靶器官的损害，是造成其病死率高的主要原因。有效的抗高血压治疗可对高血压靶器官起到保护作用。本实验旨在观察四逆汤对肾性高血压大鼠的血压及心、