关于益气活血化痰方对慢性阻塞性肺疾病模型大鼠肺组织病理学的影响.doc

关于益气活血化痰方对慢性阻塞性肺疾病模型大鼠肺组织病理学的影响 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：关于益气活血化痰方对慢性阻塞性肺疾病模型大鼠肺组织病理学的影响 1 1 材料与方法 3 2 结果 4 3 讨论 5 文2：益气活血清热利湿方对大鼠前列腺增生模型激素 7 1 材料与方法 7 2 结果 8 4组大鼠体重、前列腺湿重、前列腺体积、前列腺指数变化 8 4组大鼠血清t、e2、e2变化 9 3 讨论 9 参考文摘引言： 10 原创性声明（模板） 12 文章致谢（模板） 12 正文 关于益气活血化痰方对慢性阻塞性肺疾病模型大鼠肺组织病理学的影响 文1：关于益气活血化痰方对慢性阻塞性肺疾病模型大鼠肺组织病理学的影响 Abstract：Objective To establish chronic obstructive pulmonary disease (COPD) rat models， and to study the intervention of the formula of nourishing Qi， activating blood circulation and dispeing phlegm recipe on the morphology. Method To establish rat COPD models by intratracheal itillation of lipopolysaccharide and exposure to cigarette smoke. To itill intervention drug daily either the formula of nourishing Qi， activating blood circulation and dispeing phlegm recipe or the roxithromythin， starting on the 20th， 30th and 40th day of the experiment respectively (the groups was named h 20， h 30， h 40， r 20， r 30 and r 40 for short)， and to observe the effect on the morphology by mea of collagen staining and image analyzer. Results The pathological changes and lung function in the model group were accorded with the human COPD. In drug intervention groups， airway inflammation and epithelial proliferation were alleviated to different degree compared to the model group. In model group， the collagen deposition was increased predominant type I collagen compared to the health comtrol group， and the deposition in the drug intervention groups were decreased compared to the model group， according to the Sirius redpolarizing microscopy morphometry method. The thickness of the airway wall in the model group was significantly increased compared to the health control group (P Key words：nourishing Qi and activating blood circulation and dispeing phlegm recipe；chronic obstructive pulmonary disease；animal model 慢性阻塞性肺疾病(chronic obstructive pulmonary isease，COPD)是以不完全可逆的气流受限为特征，常呈进行性加重，且多与肺部对有害气体或有害颗粒的异常炎症反应有关[1]。其主要