187-1-N-WASP-inhibitor-TFA-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE 187-1, N-WASP inhibitor TFA Cat. No.: HY-P1045A 分⼦式: C₉₈H₁₂₃F₃N₁₈O₁₈ 分⼦量: 1898.13 Sequence: Cyclo[Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}-Gln-Lys-{d -Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}] Sequence Shortening: Cyclo[QK-{d-Phe}-{d-Pro}-{d-Phe}-F-{d-Pro}-QK-{d-Phe}-{d- Pro}-{d-Phe}-F-{d-Pro}] 作⽤靶点: Arp2/3 Complex 作⽤通路: Cytoskeleton 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 187-1, N-WASP inhibitor TFA 是⼀种14-aa 环肽，也是⼀种变构神经 Wiskott Aldrich 综合征蛋⽩ (N-WASP) 抑 制剂。187-1, N-WASP inhibitor TFA 有效抑制由磷脂酰肌醇 4,5-⼆磷酸酯 (PIP2) 诱导的肌动蛋⽩装配，IC50 为 2 μM。187-1, N-WASP inhibitor TFA 通过稳定蛋⽩质的⾃抑制状态，阻⽌了 N-WASP 激活 Arp2/3。 REFERENCES [1]. Peterson, et al. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10624-9. [2]. S Suetsugu, et al. Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by