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ObesityPillars2(2022)100018
Anti-ObesityMedicationsandInvestigationalAgents:AnObesityMedicineAssociation(OMA)ClinicalPracticeStatement(CPS)2022
HaroldE.Baysa,*,AngelaFitchb,SandraChristensenc,KarliBurridged,e,JustinTondtf
LouisvilleMetabolicandAtherosclerosisResearchCenter,UniversityofLouisvilleSchoolofMedicine,3288IllinoisAvenue,Louisville,KY,40213,USA
AssistantProfessorofMedicineHarvardMedicalSchool,Co-DirectorMassachusettsGeneralHospitalWeightCenter,Boston,MA,USA
IntegrativeMedicalWeightManagement,2611NE125thSt,Suite100B,Seattle,WA,98125,USA
EnaraHealth,16501106thCourt,OrlandPark,IL,60467,USA
GainingHealth,528PennsylvaniaAve#708,GlenEllyn,IL,60137,USA
DepartmentofFamilyandCommunityMedicine,EasternVirginiaMedicalSchool,P.O.Box1980,Norfolk,VA,23501,USA
ARTICLEINFO
ABSTRACT
Keywords:
Anti-obesitymedications
Investigationalagents
Obesity
Semaglutide
Tirzepatide
Background:This“Anti-ObesityMedicationsandInvestigationalAgents:AnObesityMedicineAssociationClinicalPracticeStatement2022”isintendedtoprovidecliniciansanoverviewofFoodandDrugAdministration(FDA)approvedanti-obesitymedicationsandinvestigationalanti-obesityagentsindevelopment.
Methods:Thescienti?cinformationforthisClinicalPracticeStatement(CPS)isbaseduponpublishedscienti?ccitations,clinicalperspectivesofOMAauthors,andpeerreviewbytheObesityMedicineAssociationleadership.
Results:ThisCPSdescribespharmacokineticprinciplesapplicabletothosewithobesity,anddiscussestheef?cacyandsafetyofanti-obesitymedications[e.g.,phentermine,semaglutide,liraglutide,phentermine/topiramate,naltrexone/bupropion,andorlistat,aswellasnon-systemicsuperabsorbentoralhydrogelparticles(whichistechnicallyclassi?edasamedicaldevice)].Othermedicationsdiscussedincludesetmelanotide,metreleptin,andl
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