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表观遗传修饰与肿瘤
18 1 Vol. 18, No. 1
2006 2 Chinese Bulletin of Life Sciences Feb., 2006
1004-0374(2006)01-0010-05 · ·
200001
DNA
D N A
R730.2; R730.59 A
Epigenetic modification and cancer
LU Rong, FANG Jing-Yuan*
(Shanghai Institute of Digestive Disease, Shanghai Jiaotong University Medical School,
Renji Hospital, Shanghai 200001, China)
Abstract: Carcinogenesis springs from the combined forces of both genetic and epigenetic events. Although
the importance of genetic mutations and deletion in cancer have long been recognized, the role of epigenetic
modification including DNA methylation and histone modification has been suggested more recently. An
epigenetic event alters the activity of genes without changing their structure. This review focuses on the
epigenetic molecular mechanisms involved in cancer onset and progression, and discusses the possibility of
new strategies in the development of anticancer treatments.
Key words: cancer; epigenetic modification; DNA methylation; histone acetylation
20 70
(Epigenetics)
1
DNA
1942
2005-11-21
(2005CB52
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