口腔黏膜病2.doc

上海交通大学口腔医学院 教 案 课程名称口腔组织病理学 第 13 次课 2011年11 月 7日 教师姓名 王丽珍 职称 副教授 教研室 口腔基础 教学时数 2 授课题目 第十三章口腔粘膜病(二) 口腔医学院102教室 理论课 粘膜斑纹性疾病－红斑、扁平苔藓、慢性盘状红斑狼疮的病理变化(将斑纹性疾病的定义、临床表现及病理变化进行比较讲解，突出差异点) 粘膜发疱性疾病－天疱疮的临床表现和病理变化(抓住病变的特征，将临床表现和病理变化结合起来讲解) 本课的难点(对策) 红斑、扁平苔藓、慢性盘状红斑狼疮的临床表现和病理变化的区别(临床表现按年龄和性别、好发部位、病变表现，病理变化按粘膜的层次，对三种疾病进行比较讲解) 天疱疮、复发性阿弗它溃疡的临床表现和病理变化(抓住两种病变的特征，把临床表现和病理变化结合起来讲解)Leon Barnes: Surgical Pathology of the Head and Neck Second Edition Marcel Dekker, Inc 2001 许国祺等：口腔癌前病变－白斑与扁平苔藓 中国医药科技出版社 1992 陈约翰等：口腔粘膜病 人民卫生出版社 1983 口腔专业杂志有关文献。 Erythroplakia(15minutes totally) Definition Clinical Features Age-sex Structures Involved Sites & the Rate of Canceration Clinical Types: homogenous, interspersed, granular(different displays) Histopathologic Features Thickness of the Epithelium The Lack of Keratinization Dysplasia, CIS, or SCC Treatment and Prognosis The Definition of Precancer Condition Chronic Discoid Lupus Erythematasus Epidemiology Clinical Features Age-sex Structures Involved Sites: Skin-the face Oral Mucosa-the lower lip Clinical display: Skin-papilionaceous red patch Oral Mucosa-central atrophy, keratinized plaque, radiating white striae Histopathologic Features Thickness of the Epithelium Parakeratinization or Hyperkeratinization Hydropic Degeneration of the Basal Cell Layer Lymphocytic Infiltrate Perivascularly Dysplasia Lichen Planus Clinical Features Age-sex Structures Involved Sites Clinical Displays: popular, reticular, plaque-like atrophic, erosive and bullous Histopathologic Features Thickness of the Epithelium Hyperkeratinization 2nd Class Hour Basal Cell Liquefaction Degeneration Dense Lymphocytic Infiltrate in the Lamina Porpria Saw-tooth-like Epithelial Rete-ridges Dysplasia Pemphigus Epidemiology Clinical Features Age-sex Structures Clinical Displays: Bullae and Break Readily Special Symptoms Histopathologic Features Suprabasal Bullae Tzanck Cells Irregular Upward Growth of