2018-02+Science增刊-肿瘤免疫治疗.docx

Precision medicine and cancer immunology in ChinaAbout the cover: An artist’s depiction of two traditional Chinese dragons surrounding a black pearl, symbolizing how precision medical treatment can overcome tumor cells using genetic research.Cover: ? 2018 Haitao Zhao (PUMCH) Design company: JzhmedThis supplement was produced by the Science/ AAAS Custom Publishing Office and sponsored by BeiGene, Ltd. Editors: Sean Sanders, Ph.D.; Jackie Oberst, Ph.D.Proofreader/Copyeditor: Bob French Designer: Amy HardcastleMaterials that appear in this supplement have not been peer-reviewed nor have they been assessed by Science. Articles can be cited using the following format: [AUTHOR NAME(S)] [CHAPTER TITLE] in Precision medicine and cancer immunology in China. (Science/AAAS, Washington, DC, 2018), p. [xx-xx].Xiaoying Chu Director, Global Collaboration and Business Development, Asia xchu@ +86-131-6136-3212Danny ZhaoRegional Sales Manager, Asia dzhao@ +86-131-4114-0012? 2018 by The American Association for the Advancement of Science. All rights reserved. 2 February 2018Articles continued29Precision cancer medicine and immunology in China Xu-Chao Zhang and Yi-Long Wu35From big data to knowledge in precision medicine Dechao Bu, Shaoliang Peng, Haitao Luo et al.38The role of circulating cell-free DNA in the management of cancer in China Ying Hu, Yanhui Chen, Lei Zhang et al.44Next-generation sequencing–based testing for cancer precision medicine in China: A review of technologies and validation procedures Weifeng Wang, Weiwei Shi, Ming Yao et al. 49ctDNA-NGS: The key to unlocking a molecular diagnostic revolution in the heart of Asia Ying Hou and Kang Ying52Adoptive cell transfer therapy: A strategic rethinking of combination cancer therapy Minghui ZhangINTRODUCTIONSne might argue that the concept of personalized medicine—in which a treatment is tailored for a specific individual based on their unique physiology as well as their specific disease and drug tolerance—is a foundat