新生儿胼胝体长度与孕周、出生体重的相关性研究.docxVIP

新生儿月并服体长度与孕周、出生体重 的相关性研究 【摘要】目的通过超声探测不同孕周、 体重的新生儿出生时脐服体长度，为早期无 创、定量评价早产儿脑发育状况奠定基础。 方法156例新生儿，男86例，女70例，包 括早产儿96例，平均孕周 土，平均出生体 重g,于生后当天在静息或睡眠状态下接受 经前囱门矢状位颅脑超声探查， 脐服体长度 为从膝部至压部。结果随着孕周和体重的 增加，月并服体长度逐步增加，早产儿平均月并 服体长度mm,与同期60例足月儿月用抵体长 度mni匕较，差异有统计学意义；脐服体长 度与出生体重的相关系数为，与孕周的相关 系数为。不同性别之间脐服体长度差异无统 计学意义。结论 出生时月并服体长度受出生 体重、孕周大小的影响，但不受性别影响。 【关键词】 颅脑超声检查；月并服体；早产 儿；新生儿；脑发育；体重 Abstract : Objective To provide basis for assessing cerebral development in premature infant by measuring the length of corpus callosum(CC) in different gestational age and birth weight infant by means of ultrasound We recruited 156 infants including male 86, female 70,and among them, 96 cases was premature infants whose average gest ational age was 士 wk, average birth weight was ± At the first day of life, the sagittal midline cranial sonographic images of CC were obtained through anterior fontanelle under the circumstance of quiescent or sleep stage, the length of CC was measured from the genu to splenium. Results The length of CC depend on gestational age and birth weight, the average length of CC was 士 mm in premature infants, significantly shorter than those in 60 term infants ( 士) The length of CCwas correlated well with birth weight (r=, ) and gestational age (r= , ). The discrepancy of length of CC between male and female infant have no statistical significance(). Conclusion The length of CCat birth was influenced by gestational age and birth weight, but was not influenced by sex. Key words : cranial sonography; corpus callosum; premature infants; neonate; cerebral development; weight 早产儿脑发育不成熟，加上各种围生期 因素，存在脑发育迟滞的可能。月用抵体是两 侧大脑半球主要的白质连接，月并服体的生长 情况可以反映复杂的脑神经结构发育的总 体情况［1?2］。国外已有颅脑超声监测胎儿、 早产儿月并服体生长发育的报道［1?6］。新 近的研究显示早产儿出生后的运动发育迟 滞与2?6周龄时月并月氐体长度生长率低下有 关［1?2, 7］。目前还缺乏完整的不同孕周、 体重新生儿月并服体宫外超声测量值， 尤其是 长度的超声测量值，这些参考值有助于我们 了解早产儿脐服体发育的规律，本研究对 156例不同孕周和出生体重新生儿的脐服体 矢状长度进行超声测量，以期填补此方面研 究的某些不足。 1资料与方法 对象我院新生儿病区及产科母婴同室 新生儿156例，其中男86例，女70例，早 产儿96例，足月儿60例，所有患儿均除外 严重的先天异常，以上研究均通过了家长的 同意。 仪器与方法超声诊断仪为飞利浦 M2540A探头为C8 5新生儿