海昆肾喜联合渴络欣治疗糖尿病肾病的临床疗效观察.doc

海昆肾喜联合渴络欣治疗糖尿病肾病的临床疗效观察 摘要目的：探讨海昆肾喜联合渴络欣治疗糖尿病肾病的临床疗效。方法：按照数字随机分 组法将我院收治的252例DN患者均分为联合组、海昆肾喜组和渴络欣组，在常规糖尿病治 疗基础上，联合组给予海昆肾喜联合渴络欣治疗，海昆肾喜组仅给予海昆肾喜治疗，渴络欣 组仅给予渴络欣治疗，比较3组患者临床疗效及治疗前、后FBG、TG、TC、LDL?C、HDL?C、 BUN、Scr、mAlb、UTP变化情况。结果：联合纟H.患者治疗显效率及总有效率均明显高于海 昆肾喜组和渴络欣组，并异均具有显著性(P0.05)； 3纽?患者治疗后FBG未发生明显变化， 均在7.8mmol/L以下；3组患者治疗后TG、TC、LDL-C和HDL?C均发生明显变化，与治 疗前比较，差异均具有显著性(P0.05)；联合组患者治疗后TG、TC和LDL-C均明显低于 海昆肾喜组和渴络欣组，HDL?C明显高于海昆肾喜组和渴络欣组，差异均具有显著性(PV 0.05)； 3组患者治疗后BUN、Scr、mAlb和UTP均明显降低，与治疗前比较，差异均具有 显著性(P0.05)；联合组患者治疗后BUN、Scr、mAlb和UTP均明显低于海昆肾喜组和渴 络欣组，羌异均具有显著性(P0.05)o结论：海昆肾喜联合渴络欣治疗糖尿病肾病可达到优 势互补的效果，延缓肾功能损伤疗效显著，无不良反应，临床应用和推广价值较高。 关键词海昆肾喜；渴络欣；糖尿病肾病；疗效 中图分类号：R587.2 文献标识码：A Efficacy of Haikunshenxi with Keluoxin in the treatment of diabetic nephropathy Abstract Objective To investigate therapeutic effect of Haikunshenxi with Keluoxin in the treatment of diabetic nephropathy. Methods 252 cases with DN were randomly divided into com bin ation therapy group, Haikunshenxi group and Keluoxin group, on the bases of conventional therapy, combination therapy group were treated by Haikunshenxi with Keluoxin, Haikunshenxi group were treated by Haikunshenxi, Keluoxin group were treated by Keluoxin. The clinical effects and the change of FBG^ TG、TC、LDL-C HDL-C BUN Scr mAlb UTP were compared. Results Thetreatment efficiency of combination therapy group was significantly higher than Haikunshenxi group and Keluoxin group(P0.05); there was not evident change for FBG after treatment, it was below 7.8mmol/L; TG, TC, LDL-C and HDL-C were quite different after treatment, there was significant difference before and after the treatment (P0.05); the TG, TC and LDL-C of combination therapy group was significant lower than Haikunshenxi group and Keluoxin group(P0.05); the BUN, Scr, mAlb and UTP of the three groups were significant lower than before treatment(P0.05); the BUN, Scr, mAlb and UTP of combination therapy group was significant lower than Haikunshenxi group and Keluoxin group(P0.05). Conclusion Combining Haikunshe