粒细胞集落刺激因子对儿童急性粒细胞性白血病的疗效及安全性（医学资料）.docVIP

粒细胞集落刺激因子对儿童急性粒细胞性白血病的疗效及安全性（医学资料） 文档信息 主题： 关于“医学心理学”中“肿瘤学”的参考范文。 属性： F-01L81L，doc格式，正文18442字。质优实惠，欢迎下载！ 适用： 作为医学资料、医学资料写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 目录 TOC \o "1-9" \h \z \u 目录 1 正文 1 文1：粒细胞集落刺激因子对儿童急性粒细胞性白血病的疗效及安全性 2 1 对象与方法 3 2 结 果 4 3 讨 论 5 文2：儿童急性呼吸窘迫综合征的临床治疗分析 6 1 资料与方法 6 2 结果 7 3 讨论 8 4 参考文献 9 参考文摘引言： 9 原创性声明（模板） 11 文章致谢（模板） 11 正文 粒细胞集落刺激因子对儿童急性粒细胞性白血病的疗效及安全性（医学资料） 文1：粒细胞集落刺激因子对儿童急性粒细胞性白血病的疗效及安全性 ［ABSTRACT］ObjectiveTo investigate the effect of recombinant human granulocyte colonystimulating factor （rhGCSF） on children with acute myeloid leukemia (AML) and its safety. MethodsSeventeen children with AML whose absolute value of neutrophilic granulocyte (AVNG) lower than ×109/L after chemotherapy was 64 casetimes, in which, 42 casetimes received rhGCSF, and control group, 25 casetimes， without rhGCSF treatment. Comparison of several clinical paramete, . the time needed for ANC reached ×109/L, the incidence of infection, fever, application of antibiotics, hospitalization, and blood trafusion, were made between the two groups. ResultsAll the clinical paramete observed in this study were significantly different between the two groups with the results favourable for patients treated with rhGCSF. But the volume of blood trafusion was not different between the two groups. The advee effects of rhGCSF were not obvious. After rhGCSF therapy, increase of the myeloblast and promyelocyte count in bone marrow and recurrence induced by rhGCSF were not observed. ConclusionrhGCSF is effective and safe for children with acute myeloid leukemia. ［KEY WORDS］granulocyte colonystimulating factor, recombinant; leukemia, myelocytic, acute; drug therapy; advee effects; children 随着联合大剂量化疗的应用，儿童急性粒细胞性白血病（AML）的缓解率及长期生存率已大大提高，但大剂量化疗可造成骨髓抑制、粒细胞减少而易并发各种严重感染，甚至危及生命［1］，是造成病儿早期死亡的主要原因。粒细胞集落刺激因子（GCSF）为特异性粒系造血因子，它可以促进粒系细胞增殖、分化、释放及增强粒细胞的功能，加快造血重建，减少感染并发症。然而，GCSF也可以促进静止期的AML细胞进入S期，因此有学者认为，GCSF能促进AML细胞增殖，导致白血病复发。2003年6月～2006年5月，我科对17例骨