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Chin J Pharm Anal2010, 30( 8) ! 1527 !
LC-MS/MS
*
36
1 2 1 1 1 1 2
李丹, 文红梅 , 崔福春, 黄亚, 郭春, 孙夏荣, 杨婧平
( 1. 210015; 2. 210029 )
: 36: -
TM
(LC- MS/M S), Sunfire C ( 21mm 100mm, 50 m), - 01% ( 75 25),
18
( SI) (MRM ) , 36:
36, 20 ng:,
: ;; ;
: R917 : A : 0254- 1793( 2010) 08- 1527- 06
LC-MS/MS screening for 36 chemical components in
*
health food andChinese traditionalpatentmedicine
1 2 1 1 1
LIDan ,W N Hong- mei, CU IFu- chun, HUANG Ya, GUO Chun ,
1 2
SUN Xia- rong, YANG Jing- ping
( 1. Nanjing Institute for D rug Control, N anjing 210015, China; 2. N anjing University of Traditional ChineseM edicine, Nanjing 210029, China)
Abstract Objective:To establish a liquid chromatography- tandem mass chrom atography (LC- MS /MS) m ethod
for the smi ultaneous screening 36 chem ical components in health food and Chinese T raditional PatentM edicine.
Methods:Thismethod involves liquid chromatography- tandem mass spectrometry, the separation was conducted by
TM
Sunfire C ( 21mm 100 mm, 50 m). Themobile phase consisted of 01% form ic andmethanol (25 75).
18
The target compoundswere analyzed w ith LC- MS/MS- SI. Multiple- reaction monitoring (MRM ) was used to
screen 36 chem ical components in health food and Chinese T raditional PatentM edicine. esults:A fast and sensi
tive liquid chr
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