LC_MS_MS法快速测定中成药_保健食品中非法添加的36种化学成分.pdf

LC_MS_MS法快速测定中成药_保健食品中非法添加的36种化学成分.pdf

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Chin J Pharm Anal2010, 30( 8) ! 1527 ! LC-MS/MS * 36 1 2 1 1 1 1 2 李丹, 文红梅 , 崔福春, 黄亚, 郭春, 孙夏荣, 杨婧平 ( 1. 210015; 2. 210029 ) : 36: - TM (LC- MS/M S), Sunfire C ( 21mm 100mm, 50 m), - 01% ( 75 25), 18 ( SI) (MRM ) , 36: 36, 20 ng:, : ;; ; : R917 : A : 0254- 1793( 2010) 08- 1527- 06 LC-MS/MS screening for 36 chemical components in * health food andChinese traditionalpatentmedicine 1 2 1 1 1 LIDan ,W N Hong- mei, CU IFu- chun, HUANG Ya, GUO Chun , 1 2 SUN Xia- rong, YANG Jing- ping ( 1. Nanjing Institute for D rug Control, N anjing 210015, China; 2. N anjing University of Traditional ChineseM edicine, Nanjing 210029, China) Abstract Objective:To establish a liquid chromatography- tandem mass chrom atography (LC- MS /MS) m ethod for the smi ultaneous screening 36 chem ical components in health food and Chinese T raditional PatentM edicine. Methods:Thismethod involves liquid chromatography- tandem mass spectrometry, the separation was conducted by TM Sunfire C ( 21mm 100 mm, 50 m). Themobile phase consisted of 01% form ic andmethanol (25 75). 18 The target compoundswere analyzed w ith LC- MS/MS- SI. Multiple- reaction monitoring (MRM ) was used to screen 36 chem ical components in health food and Chinese T raditional PatentM edicine. esults:A fast and sensi tive liquid chr

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