老年急性脑梗死血清C 反应蛋白含量变化及与脑水肿的相关探讨.docVIP

精品论文 参考文献 老年急性脑梗死血清C 反应蛋白含量变化及与脑水肿的相关探讨 文 俊 徐 平 郭桂香 高云春 丁 涛常德市第一人民医院神经内科 湖南常德 415000 　　【摘 要】目的 探讨老年急性脑梗死血清C 反应蛋白含量变化及与脑水肿的相关性。方法 将97 例住院的急性脑梗死（ACI）老年病例依据美国国立卫生研究院卒中量表（NIHSS）评分分为3 组，即轻度组（29 例）、中度组（48 例）、高度组（20 例）。选取同期住院的非ACI 老年患者100 例设为对照组。在入院后第2、3、5、7 天ACI 病例检查C-反应蛋白（CRP）和颅脑CT，对照组检查CRP。 　　结果 轻度组、中度组和重度组的CRP 水平在各时段与对照组CRP 水平比较均有显著性差异（P 均<0.05）；轻度组、中度组和重度组三组的CRP 水平、脑水肿体积在各时段两两比较均有显著性差异（P 均<0.05）；person 分析各时段CRP 水平与脑水肿体积间的相关性，P 均<0.05，且均为正相关，第2、3、5、7 天的相关系数分别为0.574、0.643、0.675、0.662。结论 CRP 与老年ACI 患者脑水肿的程度呈正相关，可依据CRP 的变化评价脑水肿的严重程度。 　　【关键词】老年；急性脑梗死；脑水肿；C-反应蛋白Abstract Objective To investigate the correlation between the changes of C-reactive protein level and encephaledema in elderly patients withacute cerebral infarction.Methods 97 cases of elderly patients with acute cerebral infarction（ACI）were divided into 3 groups accordingto American National Institutes of Health Stroke Scale（NIHSS）scores，the mild group（29 cases），moderate group（48 cases），highly group（20 cases）.100 cases of senile patients without ACI were selected at the same time as the control group.ACI patients were detected withC-reactive protein（CRP）and brain CT after 2，3，5，7 days of admission，the control group was detected with CRP.Results CRP level inmild group，moderate group and severe group at each period were significantly different with the CRP levels of the control group（P<0.05）；CRP level and cerebral edema volume between any two groups of mild group，moderate group and severe group were significantly different（P<0.05）；person correlation analysis of CRP level and the volume of brain edema at each time period had positive correlation，P<0.05，thecorrelation coefficient at 2，3，5，7 days were respectively 0.574，0.643，0.675，0.662.Conclusion CRP has a positively correlation with the degreeof encephaledema in elderly patients with ACI，we can evaluate the severity of encephaledema according to the changes of CRP.Keywords elderly；acute cerebral infarction；encephaledema；C- reactive protein 　　老年人是急性