结外nkt细胞淋巴瘤治疗进展.ppt

培门冬酶治疗NK/T淋巴瘤 Reyes VE Jr, Al-Saleem T, Robu VG, Smith MR.Extranodal NK/T-cell lymphoma nasal type: efficacy of pegaspargase. Report of two patients from the United Sates and review of literature. Leuk Res. 2010 Jan;34(1):e50-4. 河南省淋巴瘤诊疗中心泽菲治疗NK/T细胞淋巴瘤资料 河南省淋巴瘤诊疗中心会诊病例病例1 男，28岁，鼻腔NK/T患者，ⅡB期，CHOP方案化疗1周期，疗效评价PR，继之再次CHOP方案化疗1周期后出现多发肝肺侵犯，脾大，腹膜后淋巴结肿大，胸腹水。患者发热，呼吸困难，腹胀。 给予DDGP（顺铂、地塞米松、吉西他滨、培门冬酶）方案化疗2周期后达到完全缓解，2次PET-CT检查全身无肿瘤病变，后进行了干细胞移植，现患者完全缓解已2年。 男，37岁，外周T细胞淋巴瘤患者，ⅢB期（颈部、腋窝、腹股沟、腹膜后淋巴结肿大，肝脾大），CHOP方案化疗1周期，疗效评价SD。继之换用顺铂、VP16 、Ara-C 、甲羟龙方案化疗1周期疗效评价仍为SD。 换用DDG（顺铂、地塞米松、吉西他滨）方案化疗后肿块逐步缩小，后进行了干细胞移植。1年又复发。 河南省淋巴瘤诊疗中心会诊病例病例2 盐酸吉西他滨为核苷同系物，属细胞周期特异性抗肿瘤药。主要杀伤处于S期（DNA合成）的细胞，同时也阻断细胞增殖由G1向S期过渡的进程。 吉西他滨作用机制 中山大学肿瘤医院 SUN YAT-SEN UNIVERSITY CANCER CENTER Gemcitabine treatment in cutaneous T-cell lymphoma: a multicentre study of 23 cases. Author: Jidar K, Ingen-Housz-Oro S, Beylot-Barry M, Paul C, Chaoui D, Sigal- Grinberg M, Morel P, Dubertret L, Bachelez H. Service de Dermatologie, Centre Hospitalier Victor Dupuy, Argenteuil, France Regime: Gemcitabine weekly within 21or 28 days schedule. * Br J Dermatol. 2009 Sep;161(3):660-3. Epub 2009 May 12. Result Gemcitabine(N=23) ORR 62.5% adverse events capillary leak syndrome 1 bullous and erosive dermatitis 2 Neutropenia(Pts) 7 infections 6 中山大学肿瘤医院 SUN YAT-SEN UNIVERSITY CANCER CENTER Gemcitabine as single agent pretreated T-cell NHLs: long-term outcome. Zinzani PL, Venturini F, Stefoni V, Fina M, Pellegrini C, Derenzini E, Gan Institute of Hematology and Medical Oncology CONCLUSION: In our experience, among the CR patients, 7 of 9 are in continuous complete response with a variable disease-free interval (15-120 months). Gemcitabine proved to be effective in pretreated MF and PTCLU patients, even in the long term. * Results Gem (N=39) CR 23% PR 28% ORR 51% Gem1200 mg/m2/day D1, 8, 15 , 3-6 cy Enroll 39 pretreated pts (MF=19 ,PTCLU=20) histologic diagno