2021天康集团-母猪和仔猪之间免疫学层面的互动.pdf

Immunological interactions between sows and piglets 母猪和仔猪之间免疫学层面的互动 Rongyu Zeng MS, MS, Ph.D 天康集团 rongyuzeng2011@163.com Outline大纲 • Immunological interactions between sows and piglets 母猪和仔猪之间免疫学层面的互动 • Effect of maternal immunity on the induction of humoral and cellular immunity by immunization in piglets 母源免疫力对仔猪体液和细胞免疫力的影响 • Strategies to maximize piglet immunity 仔猪免疫力最大化的策略 Immunological interactions between sows and piglets 母猪和仔猪之间免疫学层面的互动 • Prenatal period 胎儿期 Ill-defined, immune competence at late gestation 知之甚少，胎猪在怀孕后期出现免疫应答能力 • Neonatal period新生仔猪期 Immunoglobulins and immune cells in colostrum and milk 初乳和常乳中的免疫球蛋白和免疫细胞 3 Effect of maternal immunity on the induction of humoral and cellular immunity in piglets 母源免疫力对仔猪体液和细胞免疫力的影响 • Live vaccines: HC,PRV 活疫苗：猪瘟，伪狂犬 – Suppression of cellular and humoral response to HC, PRV vaccines 抑制仔猪体液和细胞免疫力的建立(Suradhat et al, 2003; Pomorska-Mol et al, 2010) • Inactivated vaccines: FMD,MH 灭活苗：口蹄疫，肺炎支原体 – Suppression of Ab response to MH,FMD vaccines 抑制仔猪MH和FMD体液免疫力(Bandrick et al, 2014; Dekker et al, 2016) – Enhancement of cellular immunity by MH vaccine 提高仔猪MH细胞免疫力(Bandrick et al, 2014) The inhibiting effect of maternal immunity on the cellular and humoral immunity against HC in piglets 母源免疫力抑制仔猪对猪瘟的体液和细胞免疫力的建立 3周NA=(8-64)的仔猪，5周免疫 NA frome8 to 64 at week 3, I.M. at week 5 3周NA=64 的仔猪，5周免疫NA=64 at week 3, I.M. at week 5 3周NA= (8 -64)的仔猪，未免疫NA from 8 to 64 at week 3, Control (Suradhat et al,2003)