犬Oddi括约肌狭窄模型的建立及其胆道动力学的变化.doc

犬Oddi括约肌狭窄模型的建立及其胆道动力学的变化.doc

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犬Oddi括约肌狭窄模型的建立及其胆道动力学的变化 目录 TOC \o "1-9" \h \z \u 目录 1 正文 1 文1:犬Oddi括约肌狭窄模型的建立及其胆道动力学的变化 1 1 材料与方法 3 2 结果 4 3 讨论 5 文2:犬Oddi括约肌肌电的研究 7 1 材料与方法 8 2 结果 10 3 讨论 11 参考文摘引言: 13 原创性声明(模板) 14 文章致谢(模板) 15 正文 犬Oddi括约肌狭窄模型的建立及其胆道动力学的变化 文1:犬Oddi括约肌狭窄模型的建立及其胆道动力学的变化 【Abstract】 Objective To establish models of sphincter of Oddi (SO) stenosis to observe their biliary dynamic changes in dogs. Methods After fasting for 16-18 hou, the adult mongrel dogs were anesthetized and performed with ultrasonograph to determine the size of the common bile duct (CBD). In the experimental group, the dogs'SO accepted mechanical damage by dissecting duodenums of the dogs. While in the control group, only sham operation was done. Liver function was checked periodically by serum examination. All dogs accepted ultrasonograph and sphincter of Oddi manometry (SOM) to determine the size of CBD and biliary dynamics respectively at postoperative four weeks. Biopsy of SO and adjacent tissue was done for pathological analysis after the second operation. Results In the experimental group, the levels of TBIL, DBIL, GCT, and ALP were higher than those before operation, and the size of CBD was larger than that before operation. SO fibrosis was found in the experimental group by pathology but not in the control group. Compared with the control group, there could be found significant increase of basal pressures of CBD and SO, decrease of the amplitude of SO and increase of the frequency of SO contraction in the experimental group. Conclusio The SO stenosis model is established successfully, when the stenosis of SO causes significant changes of biliary dynamics, with increase of basal pressure and contraction frequency, decrease of amplitude and shortening of contraction time. 【Key words】 Sphincter of Oddi; Stenosis; SO manometry; Biliary dynamics Oddi括约肌功能失调或障碍(sphincter of Oddi dysfunction,SOD)可能是胆道、胰腺及胃肠道疾病发生的重要诱因之一。近有学者建议将其分为Oddi括约肌(sphincter of Oddi,SO)狭窄和SO功能紊乱两种情况[1]。前者

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