全胃切除术后家兔营养不良的实验研究临床医学.doc

全胃切除术后家兔营养不良的实验研究临床医学 目录 TOC \o "1-9" \h \z \u 目录 1 正文 1 文1：全胃切除术后家兔营养不良的实验研究临床医学 1 1 材料与方法 3 2 结果 6 十二指肠、空肠上皮GLUT5和SGLT1 mRNA的表达 6 3 讨论 6 文2：高龄胃癌根治性全胃切除术后护理体会 10 1临床资料 10 2术前护理 10 3术后护理 11 4 讨论 13 参考文摘引言： 14 原创性声明（模板） 15 文章致谢（模板） 16 正文 全胃切除术后家兔营养不良的实验研究临床医学 文1：全胃切除术后家兔营养不良的实验研究临床医学 【Abstract】 Objective To explore preliminarily the causes for anorexia, weight reduction and malnutrition after total gastrectomy by establishing rabbit model of total gastrectomy and vagotomy. Methods Twentyfour New Zealand rabbits were divided randomly into group A (control group), group B (undergone total gastrectomy) and group C (undergone vagotomy ) . The ratio of the weight, the amount of food taken, the content of cholecystokinin (CCK) and motlin in plasma, the expression of the mRNA of GLUT5 and SGLT1 at the epithelium of the proximal part of small intestine in groups B and C after operation were observed and compared with those in group A. Results Compared with group A, the ratio of the weight and the amount of food taken in group B were reduced more distinctly. The content of motlin in group B showed little change, while the content of CCK was elevated at days 3 and 14 after operatio (P<). The expression of GLUT5 mRNA at duodenum and jejunum decreased notably in group B compared with group A (P< and P< respectively). But the expression of GLUT5 mRNA at duodenum and jejunum showed no statistical deference in group B compared with group A (P>). In group C, all these indices had no statistical deference compared with group A (P>). Conclusio After total gastrectomy, the peristalsis of small intestine and the evacuation of the food in interdigestive period correlated with motlin may not change, while the increase of the content of CCK may cause central feeding inhibition and anorexia. After total gastrectomy, the expression of GLUT5 mRNA at the proximal part of small intestine of the rabbits is decreased but that of SGLT1 mRNA remai unchan