大鼠糖尿病视网膜病变模型建立及超微结构观察医学（医学资料）.docVIP

大鼠糖尿病视网膜病变模型建立及超微结构观察医学（医学资料） 文档信息 主题： 关于“医学心理学”中“眼科学”的参考范文。 属性： F-01L80N，doc格式，正文21633字。质优实惠，欢迎下载！ 适用： 作为医学资料、医学资料写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：大鼠糖尿病视网膜病变模型建立及超微结构观察医学 2 1 材料和方法 3 2 结 果 4 3 讨 论 6 文2：糖尿病视网膜病变甲襞微循环改变的研究临床医学 7 1 资料与方法 8 2 结果 9 3 讨论 9 参考文摘引言： 10 原创性声明（模板） 11 文章致谢（模板） 11 正文 大鼠糖尿病视网膜病变模型建立及超微结构观察医学（医学资料） 文1：大鼠糖尿病视网膜病变模型建立及超微结构观察医学 ［ABSTRACT］ObjectiveTo establish a model of early diabetic retinopathy in rat and study the retinal ultrastructural changes. MethodsSixty adult male SD rats were divided into four groups: normal control group (CON), diabetes for 1 month (DM1), diabetes for 3 months (DM3), diabetes for 6 months (DM6). The diabetic rat model was induced by intraperitoneal injection of streptozotocin (STZ). Physiological facto of the rats were examined and the retinal pathology and ultrastructural changes studied. ResultsDiabetes was induced in all of the rats. The mortality of the rats was %. Ultrastructural study showed that the retina became thinner in early diabetic rats. The number of visual cells became decreased along with duration of the experiment. The capillary endothelial cells and mitochondria became swollen. The basement membrane of capillaries became thicker. There was narrowing and even occlusion of the capillary lumen. The membrane disc space of visual cell outer segment was enlarged and arranged disorderly. The mitochondria of inner segments was swollen and arranged irregularly. ConclusionThe diabetic retinopathy rat model induced by intraperitoneal injection of streptozotocin (STZ) shows similarities in the development of retinal lesio and ultrastructural changes to human diabetic retinopathy. With its easy manipulation and higher succes rate, the model can be potentially used for pathological, etiologic and therapeutic study of retinopathy. ［KEY WORDS］diabetic retinopathy; retina/ultrastructure; models, animal; rats 糖尿病视网膜病变（DR）是糖尿病病人在眼部的常见并发症之一