不同β受体阻滞剂抗家兔动脉粥样硬化作用的研究医学（医学资料）.docVIP

不同β受体阻滞剂抗家兔动脉粥样硬化作用的研究医学（医学资料） 文档信息 主题： 关于“医学心理学”中“麻醉学”的参考范文。 属性： F-01L80F，doc格式，正文20109字。质优实惠，欢迎下载！ 适用： 作为医学资料、医学资料写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：不同β受体阻滞剂抗家兔动脉粥样硬化作用的研究医学 2 1 材料与方法 3 2 结 果 5 3 讨 论 6 文2：二苯乙烯苷对动脉粥样硬化作用的研究 8 1 改善内皮细胞功能 8 2 抑制血管平滑肌细胞增殖 9 3 稳定斑块作用 10 4 抗炎作用 10 5 调脂作用 11 参考文摘引言： 11 原创性声明（模板） 13 文章致谢（模板） 13 正文 不同β受体阻滞剂抗家兔动脉粥样硬化作用的研究医学（医学资料） 文1：不同β受体阻滞剂抗家兔动脉粥样硬化作用的研究医学 ［ABSTRACT］ObjectiveTo investigate the mechanism of carvedilol and metoprolol in different doses agait arterosclerosis and compare their therapeutic effect. MethodsMale New Zealand white rabbits (n=40) were randomly and evenly divided into five groups: normal group, highfatdiet group, lowdosemetoprolol group, highdosemetoprolol group and cavedilol group. Ten weeks later, levels of serum superoxide dismutase (SOD) and malondiadehede (MDA) were measured. Expression of PCNA and NFkBp65 in aorta was detected by with the normal group, lower level of serum SOD and higher level of serum MDA were found in the highfatdiet group （F=,;q=,;P）. No statistical differences were observed among the levels of serum SOD and MDA between the highfatdiet group and metoprolol group either in low or high dose （q=－, P）, but higher levels of serum SOD and lower levels of serum MDA were found in carvedilol group, compared with the other four groups （q=－, P）. Expression of PCNA and NFkBp65 in the aorta of the highfatdiet animals was obviously stronger than those of the normal group （F=,;q=,; P）. There existed a decreasing gradient in the expression of PCNA and NFkBp65 among the animals of high fat diet, lowdose metoprolol, highdose metoprolol and cavedilol group （q=－, P）. A positive correlation was found in the expression of PCNA and NFkBp65 among the five groups (r=, P）. ConclusionBoth metoprolol and cavedilol posses antiarteroscleotic effect and metoprolol is of dosedependent. Carvedilol is better than metopro