Asthma Pregnancy Alters Postnatal Development of Chromaffin Cells in the Rat Adrenal Medulla 英文参考文献.docVIP
- 1、本文档共10页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Asthma Pregnancy Alters Postnatal Development of Chromaffin Cells in the Rat Adrenal Medulla 英文参考文献
AsthmaPregnancyAltersPostnatalDevelopmentof
ChromaffinCellsintheRatAdrenalMedulla
Xiu-MingWu.,Cheng-PingHu.,Xiao-ZhaoLi,Ye-QiangZou,Jun-TaoZou,Yuan-YuanLi,Jun-TaoFeng*
DepartmentofRespiratoryMedicine,XiangyaHospital,CentralSouthUniversity,Changsha,Hunan,China
Abstract
Background:Adrenalneuroendocrineplaysanimportantroleinasthma.Theactivityofthesympathoadrenalsystemcould
bealteredbyearlylifeevents.Theeffectsofmaternalasthmaduringpregnancyontheadrenalmedullaofoffspringremain
unknown.
Methodology/PrincipalFindings:Thisstudyaimstoexploretheinfluenceofmaternalasthmaduringpregnancyonthe
developmentandfunctionofadrenalmedullainoffspringfrompostnatalday3(P3)topostnatalday60(P60).Asthmatic
pregnant rats (AP), nerve growth factor (NGF)-treated pregnant rats (NP) and NGF antibody-treated pregnant rats (ANP)
weresensitizedandchallengedwithovalbumin(OVA);NPandANPweretreatedwithNGFandNGFantibodyrespectively.
Offspringratsfromthematernalgroupweredividedintofourgroups:offspringfromcontrolpregnantrats(OCP),offspring
from AP (OAP), offspring from NP (ONP), and offspring from ANP (OANP). The expressions of phenylethanolamine N-
methyltransferase(PNMT)proteininadrenalmedullawereanalyzed.Theconcentrationsofepinephrine(EPI),corticosterone
andNGFinserumweremeasured.Adrenalmedullachromaffincells(AMCC)werepronetodifferentiateintosympathetic
nervecellsinOAPandONP.BothEPIandPNMTweredecreasedinOAPfromP3toP14,andthenreachednormallevel
gradually from P30 to P60, which were lower from birth to adulthood in ONP. Corticosterone concentration increased
significantlyinOAPandONP.
Conclusion/Significance:AsthmapregnancymaypromoteAMCCtodifferentiateintosympatheticneuronsinoffspringrats
andinhibitthesynthesisofEPI,resultingindysfunctionofbronchialrelaxation.
Citation: Wu X-M, Hu C-P, Li X-Z, Zou Y-Q, Zou J-T, et al. (2011) Asthma Pregnancy Alters Postnatal Development of Chromaffin Cells in the Rat Adrenal
Medulla.PLoSONE6(5):e20337.doi:10.1371/journal.pone.0020337
Editor:RoryEdwardMorty,UniversityofGi
您可能关注的文档
- Association between the JC Polyomavirus Infection and Male Infertility 英文参考文献.doc
- Association of 25 bp Deletion in MYBPC3 Gene with Left Ventricle Dysfunction in Coronary Artery Disease Patients 英文参考文献.doc
- Association between Variants of the Leptin Receptor Gene (LEPR) and Overweight A Systematic Review and an Analysis of the CoLaus Study 英文参考文献.doc
- Association of a Bacteriophage with Meningococcal Disease in Young Adults 英文参考文献.doc
- Association of a Bovine Prion Gene Haplotype with Atypical BSE 英文参考文献.doc
- Association between Variant Y402H in Age-Related Macular Degeneration (AMD) Susceptibility Gene CFH and Treatment Response of AMD A Meta-Analysis 英文参考文献.doc
- Association of Adenovirus 36 Infection with Obesity and Metabolic Markers in Humans A Meta-Analysis of Observational Studies 英文参考文献.doc
- Association Mapping of Insecticide Resistance in Wild Anopheles gambiae Populations Major Variants Identified in a Low-Linkage Disequilbrium Genome 英文参考文献.doc
- Association of Age with Mortality and Virological and Immunological Response to Antiretroviral Therapy in Rural South African Adults 英文参考文献.doc
- Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease 英文参考文献.doc
文档评论(0)