生物因素所致职业病.pptVIP

Similarly, studies carried out in the Federal Republic of Germany, France, the Netherlands, Norway, the UK and the USA of workers in the production of chromate pigments（铬酸盐颜料） have also consistently shown excess risks for lung cancer. Workers in this industry are exposed to chromates, not only in the pigments themselves but also from soluble chromium compounds in the raw materials used in their production. 学习文档 Overall evaluation Chromium [VI] is carcinogenic to humans (Group 1). Metallic chromium and chromium compounds [III] are not classifiable as to their carcinogenicity to humans (Group 3). 学习文档 ARSENIC AND ARSENIC COMPOUNDS(砷及砷化合物) Evidence for carcinogenicity to humans (sufficient) Evidence for carcinogenicity to animals (limited) Other relevant data Overall evaluation 学习文档 Evidence for carcinogenicity to humans (sufficient) Many cases of skin cancer have been reported among people exposed to arsenic through medical treatment with inorganic trivalent arsenic compounds（无机三价砷化合物）, particularly Fowler‘s solution（福乐氏溶液）, and further reports have confirmed these findings. 学习文档 Occupational exposure （职业接触）to inorganic arsenic（无机砷）, especially in mining(采矿) and copper smelting（炼铜）, has quite consistently been associated with an increased risk of cancer. An almost ten-fold increase in the incidence of lung cancer was found in workers most heavily exposed to arsenic, and relatively clear dose-response relationships have been obtained with regard to cumulative exposure（累计暴露）. 学习文档 With regard to histological type of lung cancer, a significant, relative excess of adenocarcinomas(腺癌)and a slight excess of oat-cell(燕麦细胞)cancers were seen among smelter workers（熔炼工）. A multiplicative effect（相乘效应） of arsenic exposure and smoking was observed among Swedish smelter workers. 学习文档 Evidence for carcinogenicity to animals (limited)  arsenic compounds 砷化合物 by intratracheal instillation气管滴注 by implantation into the stomach灌胃 Carcinomas 癌 Adenomas 腺瘤 Papillomas 乳头瘤 Overall